Cell interactions with the extracellular matrix
نویسندگان
چکیده
منابع مشابه
A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis
Extracellular matrix interactions have essential roles in normal physiology and many pathological processes. Although the importance of extracellular matrix interactions in metastasis is well documented, systematic approaches to identify their roles in distinct stages of tumorigenesis have not been described. Here we report a novel-screening platform capable of measuring phenotypic responses to...
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Differentiation is a continuously regulated process and interactions between the cell and its environment play a major role in maintaining stable expression of differentiation-specific genes (Blau and Baltimore, 1991). An important component of the cellular environment is the extracellular matrix (ECM), which is composed of glycoproteins, proteoglycans and glycosaminoglycans that are secreted a...
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The extracellular matrix (ECM) provides structural and biochemical support to cells within tissues. An emerging body of evidence has established that the ECM plays a key role in cell mechanotransduction - the study of coupling between mechanical inputs and cellular phenotype - through either mediating transmission of forces to the cells, or presenting mechanical cues that guide cellular behavio...
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Cancer progression is a multistep process during which normal cells exhibit molecular changes that culminate into the highly malignant and metastatic phenotype, observed in cancerous tissues. The initiation of cell transformation is generally associated with genetic alterations in normal cells that lead to the loss of intercellular- and/or extracellular-matrix- (ECM-) mediated cell adhesion. Tr...
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ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2009
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-009-0891-x